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Learn About Treatment Options

The medicines listed below have been authorized for sale in Canada. Always talk to your healthcare professional (doctor, nurse or pharmacist) before you start taking any medicines. The information below is a summary and will not tell you everything about these medicines.

For more information about each medication, please click on one of the product tabs below to learn more about that drug.

Serious Warnings and Precautions

Hepatitis B activity (e.g., inflamed liver) may increase when taking antiviral drugs like the ones described below, sometimes leading to liver failure and death (See below “What other warning(s) should I know about?” for details about each medicine).

Daklinza®
daclatasvir
Epclusa®
sofosbuvir/
velpatasvir
Galexos®
simeprevir
Harvoni®
ledipasvir/
sofosbuvir
Holkira Pak®
Tablet 1:
ombitasvir/
paritaprevir/
ritonavir
Tablet 2:
dasabuvir
Maviret
glecaprevir/
pibrentasvir
Sovaldi®
sofosbuvir
Sunvepra
asunaprevir
Technivie
ombitasvir/
paritaprevir/
ritonavir
Vosevi
sofosbuvir/
velpatasvir/
voxilaprevir
Zepatier®
elbasvir/
grazoprevir
Who is this medicine for?

Daklinza® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C infection.

Epclusa® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Galexos® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Harvoni® is used to treat adults (18 years of age or older) and children (12 to under 18 years of age) with chronic (long-lasting) hepatitis C.

Holkira Pak® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Maviret is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C infection.

Sovaldi® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Sunvepra™ is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Technivie™ is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

Vosevi is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C who have:

  • Genotype 1, 2, 3, 4, 5 or 6 infection and have been previously treated with a type of medicine called an NS5A inhibitor
  • Genotype 1, 2, 3 or 4 infection and have been previously treated with sofosbuvir without another medicine called an NS5A inhibitor

Zepatier® is used to treat adults (18 years of age or older) with chronic (long-lasting) hepatitis C.

What hepatitis C virus genotypes can it treat?

Genotypes 1, 2 or 3

Genotypes 1, 2, 3, 4, 5 or 6

Genotypes 1 or 4

Adults (18 years of age or older): genotypes 1, 2, 3, 4, 5 or 6
Children (12 to under 18 years of age): genotype 1

Genotype 1

Genotypes 1, 2, 3, 4, 5 or 6

Genotypes 1, 2, 3 or 4

Genotypes 1 or 4

Genotype 4

Genotypes 1, 2, 3, 4, 5 or 6

Genotypes 1, 3 or 4

How is this medicine taken?

One tablet once a day with or without food

Do not take Daklinza® alone. Your healthcare professional will tell you what other medicines you should take with Daklinza®.

One tablet once a day with or without food

Your healthcare professional may decide to prescribe Epclusa® in combination with ribavirin.

One capsule once a day with food

Galexos® is used together with other medicines for the treatment of hepatitis C infection.

One tablet once a day with or without food

Your healthcare professional may decide to prescribe Harvoni® in combination with ribavirin.

Every morning: Take two pink tablets and one beige tablet with food.
Every evening: Take one beige tablet with food.

Your healthcare professional may decide to prescribe Holkira Pak® in combination with ribavirin.

Three tablets all at once each day with food

One tablet once a day with or without food

Sovaldi® should not be used alone. It is used in combination with ribavirin or pegylated interferon and ribavirin. Read the ribavirin and/or pegylated interferon patient medication information if your healthcare professional says you should also take ribavirin or pegylated interferon and ribavirin.

One capsule twice a day with or without food

Do not take Sunvepra™ alone. Sunvepra™ is used with daclatasvir (Daklinza®) or daclatasvir (Daklinza®) with peginterferon alfa and ribavirin.

Two tablets once a day in the morning with food

Your healthcare professional may decide to prescribe Technivie™ in combination with ribavirin.

One tablet once a day with food.

One tablet once a day at the same time every day, with or without food

Your healthcare professional may decide to prescribe Zepatier® with ribavirin or sofosbuvir.

How long will I take this medicine for?

12 or 24 weeks

Your healthcare professional will decide how long you need to take this medicine.

12 weeks

12, 24 or 48 weeks

Your healthcare professional will decide how long you need to take this medicine.

8, 12 or 24 weeks

Your healthcare professional will decide how long you need to take this medicine.

12 or 24 weeks

Your healthcare professional will decide how long you need to take this medicine.

8, 12 or 16 weeks

Your healthcare professional will decide how long you need to take this medicine.

12 or 24 weeks

Your healthcare professional will decide how long you need to take this medicine.

24 weeks

12 weeks

12 weeks

8, 12 or 16 weeks

Your healthcare professional will decide how long you need to take this medicine.

When do I not take this medicine?
  • If you are allergic to this medicine or any of the other ingredients in this product.
  • If your healthcare professional says you should use ribavirin with this medicine and you or your partner are pregnant or thinking about becoming pregnant.

Do not take Daklinza® if you are taking:

  • carbamazepine (Carbatrol®*, Epitol®* Equetro®*, Tegretol®) or oxcarbazepine (Oxtellar XR®*, Trileptal®)
  • dexamethasone (when administered by injection or taken by mouth)
  • phenobarbital (Luminal®*)
  • phenytoin (Dilantin®, Phenytek®*)
  • rifabutin (Mycobutin®)
  • rifampin (Rifadin®, Rifamate®*, Rifater®, Rimactane®*)
  • rifapentine (Priftin®*)
  • St. John’s wort (Hypericum perforatum) or a product that contains St. John’s wort

* Not sold in Canada.

  • If you are allergic to this medicine or any of the other ingredients in this product.
  • If your healthcare professional says you should use ribavirin with this medicine and you or your partner are pregnant or thinking about becoming pregnant.
  • If you are allergic to this medicine or any of the other ingredients in this product.
  • if your healthcare professional says you should use ribavirin with this medicine and you or your partner are pregnant or thinking about becoming pregnant.
  • If you are allergic to this medicine or any of the other ingredients in this product.
  • if your healthcare professional says you should use ribavirin with this medicine and you or your partner are pregnant or thinking about becoming pregnant.
  • If you are allergic to this medicine or any other ingredients in this product.
  • if your healthcare professional says you should also use ribavirin and you or your partner are pregnant or planning to become pregnant.
  • If you have moderate or severe loss of liver function
  • alfuzosin hydrochloride (Xatral®)
  • astemizole*
  • bosentan (Tracleer®)
  • carbamazepine (Tegretol®)
  • cisapride*
  • colchicine for patients who have certain kidney or liver problems
  • dronedarone (Multaq®)
  • efavirenz-containing medicines (Sustiva®, Atripla®)
  • ergot-containing medicines including:
    • ergonovine*
    • ergotamine tartrate*
    • ergotamine (Bellergal Spacetabs®)
    • dihydroergotamine mesylate (Migranal®)
    • methylergonovine*
  • ethinyl estradiol-containing medicines such as those contained in most contraceptive pills and vaginal rings used for contraception
  • etravirine (Intelence®)
  • fusidic acid (systemic)*
  • gemfibrozil
  • lovastatin
  • lurasidone (Latuda®)
  • midazolam (when taken by mouth)
  • modafinil (Alertec®)
  • nevirapine (Viramune®)
  • phenytoin (Dilantin®)
  • phenobarbital
  • pimozide (Orap®)
  • rifampin (Rifadin®, Rifater®, Rofact®)
  • salmeterol (Advair Diskus®, Serevent Diskus®)
  • sildenafil citrate (Revatio®) for the lung problem, pulmonary artery hypertension (PAH)
  • simvastatin
  • St. John's wort (Hypericum perforatum) or products containing St. John's wort
  • terfenadine*
  • triazolam

* Not sold in Canada.

  • If you are allergic to this medicine or any of the other ingredients in this product.
  • If your healthcare professional has told you that you have severe loss of liver function.
  • atazanavir (Evotaz®, Reyataz®)
  • atorvastatin (Lipitor®)
  • dabigatran etexilate (Pradaxa®)
  • ethinyl estradiol-containing medicines such as tablets or vaginal rings used to prevent pregnancy
  • rifampin (Rifadin®, Rofact®)
  • simvastatin (Zocor®)
  • If you are allergic to this medicine or any other ingredients in this product.
  • If you or your partner are pregnant or thinking about becoming pregnant.
  • If you are allergic to this medicine or any other ingredients in this product.
  • If your healthcare professional advises you to take ribavirin and peginterferon alfa with this medicine and you or your partner are pregnant or planning to become pregnant.
  • If you have certain liver problems other than hepatitis C, as determined by your healthcare professional. Be sure to tell your healthcare professional of any liver problems you have or have had.
  • Antipsychotic agent: thioridazine*
  • Anticonvulsants: phenytoin (Dilantin®, Phenytek®*), carbamazepine (Carbatrol®*, Epitol®*, Equetro®*, Tegretol®), phenobarbital (Luminal®*), oxcarbazepine (Oxtellar XR®*, Trileptal®)
  • Anti-infective agents: rifampin (Rifadin®, Rifamate®*, Rifater®, Rimactane®*, rifabutin (Mycobutin®), rifapentine (Priftin®*), nafcillin*, clarithromycin (Biaxin®, Prevpac®*), erythromycin (E.E.S.®, Eryc™, Ery-Tab®, Erythrocin®, Erythrocin® Stearate), telithromycin*
  • Endothelin receptor antagonist: bosentan (Tracleer®)
  • Glucocorticoid, systemic: dexamethasone (when administered by injection or taken by mouth)
  • Herbal products: St. John’s wort (Hypericum perforatum) or a product that contains St. John’s wort
  • HIV non-nucleoside reverse transcriptase inhibitors: efavirenz (Sustiva®, Atripla®), etravirine (Intelence®), nevirapine (Viramune®)
  • HIV protease inhibitors: atazanavir (Reyataz®), darunavir/ritonavir, indinavir (Crixivan®), lopinavir/ritonavir (Kaletra®), nelfinavir (Viracept®), ritonavir (Norvir®), saquinavir (Invirase®), fosamprenavir (Telzir®)
  • Pharmacokinetic enhancer: cobicistat or cobicistat-containing regimen
  • Wakefulness promoting agent: modafinil (Provigil®)
  • Antifungal agents: ketoconazole (when taken by mouth) (Nizoral®), itraconazole (when taken by mouth) (Sporanox®, Onmel®*), voriconazole (when taken by mouth or administered by injection) (Vfend®), fluconazole (when taken by mouth or administered by injection) (Diflucan®), posaconazole (Posanol®)
  • Calcium channel blocker: diltiazem (Cardizem®, Dilacor XR®, Tiazac®), verapamil (Covera-HS®*, Calan®*, Verelan®)
  • Immunosuppressants: cyclosporine (Neoral®, Sandimmune®)
  • Lipid-lowering agent: gemfibrozil

* Not sold in Canada

  • If you are allergic to this medicine or any other ingredients in this product.
  • if your healthcare professional says you should also use ribavirin and you or your partner are pregnant or planning to become pregnant.
  • If your healthcare professional has told you that you have moderate or severe loss of liver function.
  • alfuzosin hydrochloride (Xatral®)
  • astemizole*
  • bosentan (Tracleer®)
  • carbamazepine (Tegretol®)
  • cisapride*
  • colchicine, for patients that have certain kidney and liver problems
  • dronedarone (Multaq®)
  • efavirenz-containing medicines (Sustiva®, Atripla®)
  • ergot containing medicines including:
    • ergonovine*
    • ergotamine tartrate*
    • ergotamine (Bellergal Spacetabs®)
    • dihydroergotamine mesylate (Migranal®)
    • methylergonovine*
  • ethinyl estradiol-containing medicines such as those contained in most contraceptive pills and vaginal rings used for contraception
  • etravirine (Intelence®)
  • fusidic acid (systemic)*
  • lovastatin
  • lurasidone (Latuda®)
  • midazolam (when taken by mouth)
  • modafinil (Alertec®)
  • nevirapine (Viramune®)
  • phenytoin (Dilantin®)
  • phenobarbital
  • pimozide (Orap®)
  • rifampin (Rifadin®, Rifater®, Rofact®)
  • salmeterol (Advair Diskus®, Serevent Diskus®)
  • sildenafil citrate (Revatio®) for the lung problem, pulmonary artery hypertension (PAH)
  • simvastatin
  • St. John's Wort (Hypericum perforatum) or products containing St. John's Wort
  • terfenadine*
  • triazolam

* Not sold in Canada.

  • If you are allergic to sofosbuvir (also called Sovaldi® when it is used alone), velpatasvir (also called Epclusa® when it is used with sofosbuvir), voxilaprevir or any of the other ingredients in this product.

Do not take Vosevi if you are taking:

  • dabigatran etexilate (Pradaxa®), a drug used to treat blood clots
  • rifampin (Rifadin®, Rifater®, Rofact®), a drug used to treat tuberculosis
  • phenobarbital, a drug used to treat anxiety and to control seizures
  • phenytoin (Dilantin®), a drug used to control seizures
  • rosuvastatin (Crestor®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes
  • St. John’s wort (Hypericum perforatum), an herbal product used for anxiety or depression
  • If you are allergic to this medicine or any other ingredients in this product.
  • if your healthcare professional says you should also use ribavirin and you or your partner are pregnant or planning to become pregnant.
  • If you have moderate or severe liver problems.
  • rifampin for tuberculosis
  • HIV protease inhibitors such as atazanavir, darunavir, lopinavir, saquinavir, or tipranavir
  • efavirenz (Sustiva®) or etravirine (Intelence®) for HIV
  • cyclosporine to stop organ transplant rejection
  • carbamazepine (Tegretol®) or phenytoin (Dilantin®): medicines for epilepsy and seizures
  • St. John’s wort (Hypericum perforatum, a herbal medicine) for depression or other problems
What medicinal products may interact with the brand name medicine?

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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Daklinza® and other medicines may affect each other. This can cause you to have too much or too little Daklinza® or the other medicines in your body. The medicines may not work well or you may have side effects. Do not start taking a new medicine without talking to your healthcare professional.

Daklinza® may interact with:

  • amiodarone (Cordarone®, Pacerone®*)
  • atazanavir (Reyataz®)/ritonavir (Norvir®), and atazanavir/cobicistat (Evotaz®); you may need a lower dose of Daklinza®
  • atorvastatin (Caduet®, Lipitor®, Liptruzet™*)
  • boceprevir (Victrelis®)
  • bosentan (Tracleer®)
  • clarithromycin (Biaxin®, Prevpac®*)
  • combination of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (Stribild®); you may need a lower dose of Daklinza®
  • dabigatran etexilate mesylate (Pradaxa®)
  • digoxin (Digifab®, Digox®, Lanoxin®)
  • ditiazem (Cardizem®*, Cardizem CD®, Cardizem LA®*, Tiazac®, Cartia XT®*, Dilacor XR®*, Dilt-CD*, Diltzac*, Taztia XT*)
  • efavirenz (Sustiva®, Atripla®); you may need a higher dose of Daklinza®
  • etravirine (Intelence®)
  • erythromycin
  • fluvastatin (Lescol®)
  • itraconazole (Sporanox®, Onmel®*)
  • ketoconazole (when taken by mouth) (Nizoral®); you may need a lower dose of Daklinza®
  • modafinil (Provigil®)
  • nafcillin*
  • nevirapine (Viramune®)
  • pitavastatin (Livalo®*)
  • posaconazole (Noxafil®*)
  • pravastatin (Pravachol®)
  • rosuvastatin (Crestor®)
  • simvastatin (Simcor®*, Vytorin®*, Zocor®)
  • telaprevir (Incivek®)
  • telithromycin (Ketek®*)
  • verapamil (Covera-HS®*, Calan®*, Verelan®)
  • voriconazole

* Not sold in Canada.

This is not a complete list of medicines that could interact with Daklinza®. Know the medicines you take. Keep a list of your medicines and show it to your healthcare professional when you get a new medicine.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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Epclusa® may interact with:

  • amiodarone (Cordarone®), a drug used to treat irregular heartbeats
  • carbamazepine (Tegretol®), a drug used to treat seizures, nerve pain, and bipolar disorder
  • digoxin (Lanoxin®, Toloxin®), a drug used to treat congestive heart failure and a certain irregular heartbeat (atrial fibrillation)
  • efavirenz (Sustiva®, Atripla®), a drug used to treat HIV
  • medicines for indigestion, heartburn, or ulcers, for example nizatidine (Axid®), famotidine (Pepcid AC®, Peptic Guard®, Ulcidine®), cimetidine (Tagamet®), ranitidine (Zantac®), esomeprazole (Nexium®), lansoprazole (Prevacid®), omeprazole (Losec®), rabeprazole (Aciphex®) and pantoprazole (Pantoloc®) or antacids (like Tums®, Rolaids® or Alka-Seltzer®) that have an ingredient to protect the stomach
  • oxcarbazepine (Trileptal®), a drug used to control seizures
  • phenobarbital, a drug used to treat anxiety and to control seizures
  • phenytoin (Dilantin®), a drug used to control seizures
  • rifabutin (Mycobutin®), a drug used to treat tuberculosis
  • rifampin (Rifadin®, Rifater®, Rofact®), a drug used to treat tuberculosis
  • rosuvastatin (Crestor®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes
  • St. John’s wort (Hypericum perforatum), an herbal product used for anxiety or depression
  • tipranavir (Aptivus®) or tipranavir and ritonavir (Aptivus® and Norvir®), drugs used to treat HIV
  • tenofovir disoproxil fumarate (Atripla®, Complera®, Stribild®, Truvada®, Viread®), to treat HIV

This is not a complete list of medicines that could interact with Epclusa®. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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Galexos® and other medicines may affect each other.

Galexos® may interact with:

  • medicine to treat irregular heart beat such as digoxin, disopyramide, flecainide, mexiletine, propafenone, quinidine (when taken by mouth) or amiodarone
  • medicine to treat bacterial infection such as clarithromycin, erythromycin (when taken by mouth or given by injection), telithromycin
  • medicine to prevent blood clots such as warfarin
  • medicine to prevent seizures such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin
  • medicine to treat fungal infection (when taken by mouth or given by injection) such as itraconazole, fluconazole, ketoconazole, posaconazole, voriconazole
  • medicine to treat infections like tuberculosis such as rifabutin, rifampin, rifapentine
  • medicine to lower blood pressure such as amlodipine, bepridil, diltiazem, felodipine, nicardipine, nifedipine, nisoldipine, verapamil (when taken by mouth)
  • steroids such as dexamethasone when administered by injection or when taken by mouth
  • medicine to treat some stomach conditions such as cisapride*
  • herbs such as milk thistle (Silybum marianum) and St. John’s wort (Hypericum perforatum) or products containing milk thistle or St. John’s wort
  • cobicistat: a product that blocks some liver enzymes and increases the levels of some medicines used to treat HIV infections
  • medicine to treat HIV such as atazanavir, darunavir with ritonavir, delavirdine mesylate, efavirenz, etravirine, (fos)amprenavir, indinavir, lopinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir
  • medicine to lower cholesterol such as atorvastatin, lovastatin, pitavastatin*, pravastatin, rosuvastatin, simvastatin
  • medicine to lower immune response or prevent organ transplant failure such as cyclosporine, sirolimus, tacrolimus
  • medicine to treat pulmonary hypertension such as sildenafil, tadalafil
  • medicine to treat trouble with sleeping and/or anxiety such as midazolam (when taken by mouth)* and triazolam
  • antihistamines astemizole* and terfenadine*
  • hepatitis C medicine, ledipasvir

* Not sold in Canada.

This is not a complete list of medicines. Know the medicines you take. Keep a list of your medicines and show it to your healthcare professional when you get a new medicine. Your healthcare professional can tell you if you can take these medicines with Galexos®.

Some of these medicines may be obtained without a prescription. It is important that you carefully read the package leaflets that are provided with these medicines.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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The following may interact with Harvoni®:

  • antacids (like Tums®, Rolaids® or Alka-Seltzer®) or medicines that have an ingredient to protect the stomach, used for heartburn and indigestion
  • amiodarone (Cordarone®), a drug used to treat irregular heartbeats
  • carbamazepine (Tegretol®), a drug used to treat seizures, nerve pain and bipolar disorder
  • digoxin (Lanoxin®, Toloxin®), a drug used to treat congestive heart failure
  • tenofovir disoproxil fumarate (Atripla®, Complera®, Stribild®, Truvada®, Viread®), to treat HIV
  • medicines for indigestion, heartburn or ulcers, for example nizatidine (Axid®), famotidine (Pepcid AC®, Peptic Guard®, Ulcidine®), cimetidine (Tagamet®), ranitidine (Zantac®), esomeprazole (Nexium®), lansoprazole (Prevacid®), omeprazole (Losec®), rabeprazole (Aciphex®) and pantoprazole (Pantoloc®)
  • oxcarbazepine (Trileptal®), a drug used to control seizures
  • phenobarbital, a drug used to treat anxiety and to control seizures
  • phenytoin (Dilantin®), a drug used to control seizures
  • rifabutin (Mycobutin®), a drug used to treat tuberculosis
  • rifampin (Rifadin®, Rifater®, Rofact®), a drug used to treat tuberculosis
  • rosuvastatin (Crestor®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes
  • simeprevir (Galexos®), a drug used to treat hepatitis C
  • St. John’s wort (Hypericum perforatum), an herbal product used for anxiety or depression
  • tipranavir (Aptivus®) or tipranavir and ritonavir (Aptivus® and Norvir®), drugs used to treat HIV

This is not a complete list of medicines that could interact with Harvoni®. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

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Tell your healthcare professional all the medicines, drugs, vitamins and minerals, natural supplements or alternative medicines you are already taking. Also tell your healthcare professional if you stop any of these or start any new ones.

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Do not take Holkira Pak® with the following medicines:

  • other ritonavir-containing medicines (Norvir®, Kaletra®). When given with Holkira Pak®, atazanavir and darunavir should be taken without ritonavir.
  • amiodarone (Cordarone®)
  • alfentanil
  • disopyramide (Rythmodan®)
  • everolimus (Affinitor®, Affinitor® Disperz)
  • fentanyl (Abstral®, Duragesic®)
  • flecainamide
  • lidocaine (systemic)
  • propafenone (Rythmol®)
  • quetiapine (Seroquel®)
  • quinidine
  • rilpivirine (Edurant®, Complera®)
  • sirolimus (Rapamune®)

The following medicines may interact with Holkira Pak®:

  • alprazolam (Xanax®)
  • amlodipine (Norvasc®)
  • atazanavir (Reyataz®)
  • atorvastatin (Lipitor®)
  • carisoprodol*
  • candesartan (Atacand®, Atacand® Plus)
  • cyclobenzaprine
  • cyclosporine (Neoral®, Sandimmune®)
  • darunavir (Prezista®)
  • diazepam (Valium®)
  • digoxin (Lanoxin®)
  • diltiazem (Cardizem CD®)
  • fluticasone (Advair®, Flonase®, Flovent Diskus®, Flovent HFA®)
  • fluvastatin (Lescol®)
  • furosemide (Lasix®)
  • hydrocodone (Hycodan®, Novahistex®, Novahistine®, Tussionex®)
  • itraconazole (Sporanox®)
  • ketoconazole (Nizoral®)
  • losartan (Cozaar®, Hyzaar®)
  • nifedipine (Adalat® XL)
  • omeprazole (Losec®)
  • pitavastatin*
  • posaconazole (Posanol®)
  • pravastatin (Pravachol®)
  • rosuvastatin (Crestor®)
  • tacrolimus (Prograf®)
  • valsartan (Diovan®, Diovan® HCT)
  • verapamil (Isoptin SR®)
  • voriconazole (Vfend®)
  • warfarin (Coumadin®)

* Not sold in Canada.

Ask your healthcare professional if you are not sure if your medicine is one that is listed above. Keep a list of all the medicines you take. Show it to your healthcare professional when you get a new medicine or stop a medicine.

If you change or stop one of your other medicines while you are taking Holkira Pak®, ask your healcare professional about changing back when you are finished taking Holkira Pak®.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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If you are taking any of the medicines below, your healthcare professional may need to change your dose of these medicines.

Medicines you must tell your healthcare professional about before taking Maviret:

  • lovastatin, pravastatin (Pravachol®), rosuvastatin (Crestor®) – drugs used to lower blood cholesterol
  • carbamazepine (Tegretol®), phenobarbital, phenytoin (Dilantin®) – drugs normally used for seizures
  • cyclosporine (Neoral®, Sandimmune®), tacrolimus (Prograf®) – drugs to suppress the immune system
  • darunavir (Prezista®), efavirenz (Sustiva®, Atripla®), lopinavir/ritonavir (Kaletra®), rilpivirine (Edurant®, Complera®), ritonavir (Norvir®) – drugs for HIV infection
  • digoxin (Lanoxin®) – for heart problems or high blood pressure
  • St. John’s Wort (Hypericum perforatum) – for mild depression
  • vitamin K antagonists (e.g., warfarin [Coumadin®]) – to help reduce clots from forming in the blood

This is not a complete list of medicinal products that can interact with Maviret. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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The following medicines may interact with Sovaldi®:

  • amiodarone (Cordarone®), a drug used to treat irregular heartbeats
  • carbamazepine (Tegretol®), a drug used to treat seizures, nerve pain and bipolar disorder
  • oxcarbazepine (Trileptal®), a drug used to control seizures
  • phenytoin (Dilantin®), a drug used to control seizures
  • phenobarbital, a drug used to treat anxiety and to control seizures
  • rifabutin (Mycobutin®), a drug used to treat tuberculosis
  • rifampin (Rifadin®, Rifater®, Rofact®), a drug used to treat tuberculosis
  • St. John’s wort (Hypericum perforatum), an herbal product used for anxiety or depression

This is not a complete list of medicines that could interact with Sovaldi®. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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Sunvepra™ and other medicines may affect each other. This can cause you to have too much or too little of Sunvepra™ or the other medicine in your body. The medicines may not work well or you may have side effects. Do not start taking a new medicine without telling your healthcare professional.

The following medicines may interact with Sunvepra™ and may require dosage adjustment of the other drug:

  • dabigatran (Pradaxa®) (used to prevent blood clots)
  • dextromethorphan (a cough suppressant that is an ingredient in many over-the-counter cold medicines, for example, Dimetapp, Robitussin, Theraflu, etc.)
  • digoxin (Digifab®, Digox®, Lanoxin®), flecainide (Tambocor™), propafenone (Rhythmol®) (medicines to treat irregular heartbeats)
  • hormonal contraceptives
  • midazolam (medicine used as a sedative or to prevent convulsions)
  • rosuvastatin (Crestor®), atorvastatin (Caduet®, Lipitor®, Liptruzet*), fluvastatin (Lescol®), simvastatin (Zocor®), pitavastatin*, pravastatin (Pravachol®) (medicines that lower cholesterol)
  • amitriptyline*, imipramine, nortriptyline (Aventyl®) (medicines to treat depression)

* Not sold in Canada.

This is not a complete list of medicines that could interact with Sunvepra™. Know the medicines you take. Keep a list of them with you to show to your healthcare professional when you get a new medicine.

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Tell your healthcare professional all the medicines, drugs, vitamins and minerals, natural supplements or alternative medicines you are already taking. Also tell your healthcare professional if you stop any of these or start any new ones.

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Do not take Technivie™ with the following medicines:

  • other ritonavir-containing medicines (Norvir®, Kaletra®). When co-administered with Technivie™, atazanavir or darunavir should be taken without ritonavir.
  • amiodarone (Cordarone®)
  • alfentanil
  • disopyramide (Rythmodan®)
  • everolimus (Affinitor®, Affinitor® Disperz)
  • fentanyl (Abstral®, Duragesic®)
  • flecainide
  • lidocaine (systemic)
  • propafenone (Rythmol®)
  • quetiapine (Seroquel®)
  • quinidine
  • rilpivirine (Edurant®, Complera®)
  • sirolimus (Rapamune®)

The following medicines may interact with Technivie™:

  • alprazolam (Xanax®)
  • amlodipine (Norvasc®)
  • atazanavir (Reyataz®)
  • atorvastatin (Lipitor®)
  • candesartan (Atacand®, Atacand® Plus)
  • carisoprodol*
  • cyclobenzaprine
  • cyclosporine (Neoral®, Sandimmune®)
  • darunavir (Prezista®)
  • diazepam (Valium®)
  • digoxin (Lanoxin®)
  • diltiazem (Cardizem CD®)
  • fluticasone (Advair®, Flonase®, Flovent Diskus®, Flovent HFA®)
  • fluvastatin (Lescol®)
  • furosemide (Lasix®)
  • hydrocodone (Hycodan®, Novahistex®, Novahistine®, Tussionex®)
  • itraconazole (Sporanox®)
  • ketoconazole (Nizoral®)
  • losartan (Cozaar®, Hyzaar®)
  • nifedipine (Adalat XL®)
  • omeprazole (Losec®)
  • pitavastatin*
  • posaconazole (Posanol®)
  • pravastatin (Pravachol®)
  • rosuvastatin (Crestor®)
  • tacrolimus (Prograf®)
  • valsartan (Diovan®, Diovan® HCT)
  • verapamil (Isoptin® SR)
  • voriconazole (Vfend®)
  • warfarin (Coumadin®)

* Not sold in Canada.

Ask your healthcare professional if you are not sure if your medicine is one that is listed above.
Keep a list of all the medicines you take. Show it to your healthcare professional when you get a new medicine or stop a medicine.

If you change or stop one of your other medicines while you are taking Technivie™, ask your healthcare professional about changing back when you are finished taking Technivie™.

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Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

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Vosevi™ may interact with:

  • amiodarone (Cordarone®), a drug used to treat irregular heartbeats.
  • atazanavir (Reyataz®), a drug used to treat HIV.
  • atorvastatin (Lipitor®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes.
  • carbamazepine (Tegretol®), a drug used to treat seizures, nerve pain, and bipolar disorder.
  • cyclosporine (Neoral®, Sandimmune® I.V.), a drug used to suppress the immune system.
  • digoxin (Lanoxin®, Toloxin®), a drug used to treat congestive heart failure and a certain abnormal heart rhythm (atrial fibrillation).
  • efavirenz (Sustiva®, Atripla®), a drug used to treat HIV.
  • fluvastatin (Lescol®, Lescol® XL), a drug used to treat high cholesterol and to help prevent heart attacks and strokes.
  • lopinavir, a drug used to treat HIV.
  • lovastatin (Advicor®*, Mevacor®*), a drug used to treat high cholesterol and to help prevent heart attacks and strokes.
  • medicines for indigestion, heartburn, or ulcers. Examples are nizatidine (Axid®), famotidine (Pepcid AC®, Peptic Guard®, Ulcidine®, cimetidine (Tagamet®), ranitidine (Zantac®), esomeprazole (Nexium®), lansoprazole (Prevacid®), omeprazole (Losec®), rabeprazole (Aciphex®) and pantoprazole (Pantoloc®) or antacids (like Tums®, Rolaids® or Alka-Seltzer®) that have an ingredient to protect the stomach.
  • ethinyl estradiol, a drug in some oral contraceptives used to prevent pregnancy (e.g., Alesse®, Apri®, Aviane®, Marvelon®, Seasonale®, Tri-Cyclen®, Yasmin®, Yaz®).
  • oxcarbazepine (Trileptal®), a drug used to control seizures.
  • pravastatin (Pravachol®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes.
  • rifabutin (Mycobutin®), a drug used to treat tuberculosis.
  • rifapentine*, a drug used to treat tuberculosis.
  • simvastatin (Zocor®), a drug used to treat high cholesterol and to help prevent heart attacks and strokes.
  • tenofovir disoproxil fumarate (Atripla®, Complera®, Stribild®, Truvada®, Viread®), to treat HIV.
  • warfarin (Coumadin®) or other similar medicines called vitamin K antagonists, to thin the blood. Your healthcare professional may need to test your blood more often to check how well your blood can clot.

* Not sold in Canada.

This is not a complete list of medicines that could interact with Vosevi®. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

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Tell your healthcare professional about all the medicines you take, including any prescription and non-prescription drugs, vitamins, minerals, natural and herbal supplements or alternative medicines.

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Zepatier® and other medicines may affect each other.

The following medicines may interact with Zepatier®:

Do not take Zepatier® and tell your healthcare professional if you are taking any of the following medicines:

  • bosentan (Tracleer®): for pulmonary arterial hypertension
  • modafinil (Alertec®): to help people who cannot stay awake

Tell your healthcare professional if you are taking any of the following medicines:

  • oral ketoconazole: to treat fungal infections
  • tacrolimus: to stop organ transplant rejection
  • elvitegravir, cobicistat, emtricitabine and tenofovir: a drug combination to treat HIV
  • sunitinib: to treat certain cancers

Tell your healthcare professional if you take any of the following medicines for lowering blood cholesterol:

  • atorvastatin (Lipitor®)
  • fluvastatin (Lescol®)
  • lovastatin
  • rosuvastatin (Crestor®)
  • simvastatin (Zocor®)

Know the medicines you take. Keep a list of your medicines and show it to your healthcare professional when you get a new medicine.

If any of the above apply to you (or you are not sure), talk to your healthcare professional before taking Zepatier®.

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What other warning(s) should I know about?

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Daklinza®. Talk about any health conditions or problems you may have, including if you:

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  • have liver problems other than hepatitis C infection
  • have HIV-1
  • have had a liver transplant
  • have any other medical condition
It is not known if Daklinza® passes into your breast milk. You and your healthcare professional should decide if you will take Daklinza® or breastfeed. You should not do both.
  • are taking any medications (tell your healthcare professional about all medicines you take)
  • have a rare hereditary problem of galactose intolerance (severe lactase deficiency or glucose-galactose malabsorption) as this product contains lactose

Taking antiviral drugs such as Daklinza® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death. Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment
  • to see the hepatitis B levels in your blood
  • and may order hepatitis B treatment

Heart block and a severe lowering of the heart beat have occurred in patients taking amiodarone with Daklinza® and sofosbuvir. Your healthcare professional will decide if amiodarone can be used with Daklinza® and sofosbuvir. Contact your healthcare professional if you suffer certain side effects while taking this combination (see “What side effects are possible with this treatment?” and “What serious side effects may occur with this treatment?”).

If you are taking Daklinza® with sofosbuvir (Sovaldi®), do not take other medicines that contain sofosbuvir, such as Harvoni®.

If you are pregnant or plan to become pregnant, ask your healthcare professional for advice before taking this medicine. It is not known if Daklinza® will harm your unborn baby.

Daklinza® may be used with ribavirin. Ribavirin may cause birth defects and death of the unborn baby. Extreme care must be taken to avoid becoming pregnant.

  • Females must have a negative pregnancy test before starting Daklinza® and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Daklinza® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Daklinza® and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control that you can use.
  • If you or your partner becomes pregnant while taking Daklinza® and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Pregnancy when Daklinza® is NOT taken with ribavirin:
If you are NOT taking ribavirin with Daklinza®, the following information about pregnancy applies:

  • The effects of Daklinza® on pregnancy and the unborn child are not known. Daklinza® should not be used during pregnancy. If you can become pregnant, use effective birth control during and for 5 weeks after your treatment with Daklinza® ends.
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To help avoid side effects and make sure you take your medicine properly, talk to your healthcare professional before you take Epclusa®. Talk about any health conditions or problems you may have, including if you:

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  • have liver problems other than hepatitis C infection
  • have had a recent liver transplant
  • have HIV
  • have severe kidney disease or you are on dialysis
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed; do NOT breastfeed while taking Epclusa®
  • are taking any medications that may interaction with Epclusa® (see “What medicinal products may interact with the brand name medicine?”)

Your healthcare professional may monitor your liver function during Epclusa® treatment, under some conditions.

Taking antiviral drugs such as Epclusa® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death. Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment
  • to see the hepatitis B levels in your blood
  • and may order hepatitis B treatment

If you are pregnant or plan to become pregnant, ask your healthcare professional for advice before taking this medicine. It is NOT known if Epclusa® can harm your unborn child.

Epclusa® may be used with ribavirin. Ribavirin may cause birth defects and death of the unborn baby. Extreme care must be taken to avoid becoming pregnant.

  • Females must have a negative pregnancy test before starting Epclusa® and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Epclusa® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Epclusa® and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control that you can use.
  • If you or your partner becomes pregnant while taking Epclusa® and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Another warning you should know about:
Because Epclusa® already contains sofosbuvir, do not take Epclusa® with any other medicines containing sofosbuvir (e.g., Sovaldi®, Harvoni®).

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BEFORE you use Galexos® talk to your healthcare professional if:

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  • you are a woman who is, may be, or plans to become pregnant
  • you are a man with a female partner who is, may be, or plans to become pregnant
  • you have any other liver problems in addition to hepatitis C
  • you have taken the medicines telaprevir or boceprevir
  • you have hepatitis C that is not genotype 1 or genotype 4
  • you have Human Immunodeficiency Virus (HIV) infection
  • you have or have had hepatitis B infection
  • you had or are going to have an organ transplant

It is not known if Galexos® passes into breast milk. You and your healthcare professional should decide if you will take Galexos® or breastfeed. You should not do both.

  • you have a rare hereditary problem of galactose intolerance (severe lactase deficiency or glucose/galactose malabsorption) as this product contains lactose
  • you are of East Asian descent

Taking antiviral drugs like Galexos® to treat hepatitis C infection may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have or have had a previous hepatitis B infection

Your healthcare professional may:

  • order blood tests before and after Galexos® treatment
  • check for hepatitis B in the blood
  • initiate hepatitis B treatment

Your healthcare professional will do blood tests before you start your treatment and regularly during your treatment. These blood tests are done to help your healthcare professional to:

  • check if the treatment is working for you
  • check your liver function
  • decide how long you need to take Galexos® and the other medicines used for treating your hepatitis C infection

You may be more sensitive to sunlight (photosensitivity) when taking Galexos®. During your treatment with Galexos®, use appropriate sun protection (such as a hat, sunglasses, protective clothing, or sunscreen). Especially avoid intense or prolonged exposure to sunlight (including tanning devices).

The use of Galexos® in combination with peginterferon alfa and ribavirin is associated with skin rash reactions which may be severe.

Contact your healthcare professional if you develop symptoms of skin rash and your healthcare professional will decide if you need treatment for your skin rash and/or if you need to stop taking any of your medications including Galexos®.

Galexos® combination treatment with sofosbuvir may result in slowing of the heart rate (pulse) along with other symptoms when taken with amiodarone, a medicine used to treat certain heart problems. If you are taking Galexos® with sofosbuvir and amiodarone and you get any of the following symptoms, or if you have a slow heart rate call your healthcare professional right away:

  • fainting or near-fainting
  • dizziness or lightheadedness
  • weakness, extreme tiredness
  • chest pain, shortness of breath
  • confusion or memory problems

Severe liver problems, in some cases fatal, have been reported among patients taking Galexos®. A causal link to Galexos® has not been established. Your healthcare professional may do blood tests to check your liver function during treatment with Galexos®. Your healthcare professional may tell you to stop taking Galexos® if you develop signs and symptoms of liver problems. Tell your healthcare professional right away if you develop any of the following symptoms, or if they worsen during treatment with Galexos®:

  • tiredness
  • weakness
  • loss of appetite
  • nausea and vomiting
  • yellowing of your skin or eyes
  • colour changes in your stools

Galexos® should not be used by anyone under 18 years of age because it has not been studied in this age group.

Pregnant women should not take Galexos® unless specifically directed by the healthcare professional.

When Galexos® is used with ribavirin, please read the package leaflet for ribavirin for information regarding pregnancy. Ribavirin may cause birth defects and death of the fetus.

  • If you are a woman, you must not become pregnant during treatment and for several months afterwards.
  • If you are a man, your female partner must not become pregnant during treatment and for several months afterwards.

If pregnancy occurs during this period, you must contact your healthcare professional immediately.

  • Women must use effective birth control during treatment with Galexos®.
  • When Galexos® is used with ribavirin, read the package leaflet for ribavirin for information regarding contraception requirements. You and your partner must use two effective methods of birth control during treatment and for six months afterwards. You should discuss with your healthcare professional how you or your partner can prevent getting pregnant.

Galexos® combination treatment may affect your ability to drive and use machines. Read the package inserts for the other medicines for information regarding driving and using machines. Do not drive or use machines if you feel faint or have problems with your vision.

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To help avoid side effects and make sure you take your medicine properly, talk to your healthcare professional before you take Harvoni®. Talk about any health problems you may have, including if you:

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  • have liver problems other than hepatitis C infection
  • have had a liver transplant
  • have HIV
  • have severe kidney disease or you are on dialysis
  • are pregnant or plan to become pregnant

Do NOT breastfeed while taking Harvoni®

  • are taking any medication that may interact with Harvoni®
  • if you were born with one of the rare problems of galactose intolerance (severe lactase deficiency or glucose/galactose malabsorption); Harvoni® contains lactose

Ask your healthcare professional for advice before taking this medicine.

Taking antiviral drugs such as Harvoni® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment.
  • to see the hepatitis B levels in your blood.
  • and may order hepatitis B treatment.

If you are pregnant or plan to become pregnant, ask your healthcare professional for advice before taking this medicine. It is NOT known if Harvoni® will harm your unborn baby.

Harvoni® may be used with ribavirin. Ribavirin may cause birth defects and death of the unborn baby. Extreme care must be taken to avoid becoming pregnant.

  • Females must have a negative pregnancy test before starting Harvoni® and ribavirin, every month while on these medicines, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Harvoni® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Harvoni® and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control you can use.
  • If you or your partner becomes pregnant while taking Harvoni® with ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Another warning you should know about:
Because Harvoni® already contains sofosbuvir, do not take Harvoni® with any other medicines containing sofosbuvir (e.g., Sovaldi®).

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To help avoid side effects and make sure you are using your medicines correctly, talk to your healthcare professional before you take Holkira Pak®. Talk about any health conditions or problems you may have, including if you:

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  • have any other medical condition

Ethinyl estradiol is usually found in birth control pills. However, not all birth control pills have ethinyl estradiol. You must not use medicines that have ethinyl estradiol while taking Holkira Pak®. Your healthcare professional will ask you to stop or change to a different type of birth control while you are taking Holkira Pak®.

You should not take Holkira Pak® if you are taking everolimus. The dose of everolimus cannot be adjusted to maintain the correct drug levels when given with Holkira Pak®.

If you are taking tacrolimus, you should talk to your healthcare professional about the risks and benefits of taking Holkira Pak® at the same time and consider:

  • Serious and life-threatening side effects have occurred when taking Holkira Pak® with tacrolimus.
  • Your healthcare professional may order blood tests to check tacrolimus levels in your blood at the beginning and during treatment with Holkira Pak®.

Talk with your healthcare professional if you are taking cyclosporine for your transplant. The levels of this medicine can change when taken with Holkira Pak®. Your healthcare professional will choose how much cyclosporine you need to take:

  • with Holkira Pak®
  • when you have completed Holkira Pak®
  • if you have to stop taking Holkira Pak® for any reason
  • have liver problems other than HCV infection
  • also have HIV infection

It is not known if Holkira Pak® passes into your breast milk. You and your healthcare professional should decide if you will take Holkira Pak® or breastfeed. You should not do both.

Taking antiviral drugs such as Holkira Pak® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have never been tested for hepatitis B.
  • you know you have a current hepatitis B infection.
  • you have had a previous hepatitis B infection.

Your healthcare professional may do blood tests:

  • before hepatitis C treatment.
  • to see the hepatitis B levels in your blood.
  • and may order hepatitis B treatment.
  • Females must have negative pregnancy test before starting Holkira Pak® and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Holkira Pak® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Holkira Pak® and ribavirin and for 6 months after you have stopped taking them.
  • Talk with your healthcare professional about the kind of birth control that you can use.
  • If you or your partner becomes pregnant while taking Holkira Pak® and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Other warnings you should know about:

These severe liver problems can lead to the need for a liver transplant, or can lead to death.

Rises in liver tests have occurred when the medicines that are in Holkira Pak® were taken in studies. Contact your healthcare professional right away if you have symptoms like those listed below since these may mean you have a serious problem with your liver:

  • loss of appetite (do not feel like eating)
  • stomach ache
  • swelling of your stomach area
  • nausea (feeling sick in the stomach)
  • vomiting
  • feeling tired or weak
  • yellowing of the skin and eyes
  • confusion
  • dark urine and pale stool

It is not known if taking Holkira Pak® is safe or will work in children under 18 years of age.

Your healthcare professional may do blood tests before you start taking, and while you are on your medicines. This is to help check if the medicines are working for you.

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To help avoid side effects and make sure you are using your medicines correctly, talk to your healthcare professional before you take Maviret. Talk about any health problems you may have, including if you:

(read more)
  • have liver problems other than hepatitis C infection
  • are taking other drugs for viral infections

The effects of Maviret during pregnancy are not known. Avoid pregnancy while taking Maviret. Tell your healthcare professional if you become pregnant while taking Maviret.

It is not known if Maviret passes into your breast milk. Talk to your healthcare professional about the best way to feed your baby if you take Maviret.

  • have galactose intolerance (e.g., lactase deficiency or glucose-galactose malabsorption) since this product contains lactose

Taking antiviral drugs such as Maviret may increase hepatitis B activity. This can lead to liver problems such as liver failure and death. Talk to your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may order blood tests to see if you need hepatitis B treatment.

If any of the above apply to you (or you are not sure), talk to your healthcare professional before taking MAVIRET.

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To help avoid side effects and make sure you take your medicine properly, talk to your healthcare professional before you take Sovaldi®. Talk about any health conditions or problems you may have, including if you:

(read more)
  • have liver problems other than hepatitis C infection
  • have HIV
  • have severe kidney disease
  • have any other medical condition
  • are pregnant or plan to become pregnant. It is not known if Sovaldi® can harm your unborn child.

Do not breastfeed while taking Sovaldi®.

  • are taking any medication that may interact with Sovaldi®.

Taking antiviral drugs such as Sovaldi® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment
  • to see the hepatitis B levels in your blood
  • and may order hepatitis B treatment

Ask your healthcare professional for advice before taking this medicine.

Sovaldi® must be used with ribavirin or pegylated interferon and ribavirin. Ribavirin may cause birth defects and death of your unborn baby. Extreme care must be taken to avoid becoming pregnant.

  • Females must have a negative pregnancy test before starting Sovaldi® and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Sovaldi® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Sovaldi® and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control you can use.
  • If you or your partner becomes pregnant while taking Sovaldi® and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Another warning you should know about:
Do not take Sovaldi® with any other medicine containing sofosbuvir (e.g., Harvoni®).

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To help avoid side effects and make sure you are using your medicines correctly, talk to your healthcare professional before you take Sunvepra™. Talk about any health conditions or problems you may have, including if you:

(read more)
  • have had a liver transplant, liver disease, or liver problems
  • are taking any medications

Hepatitis B activity may increase when medicines like Sunvepra™ are used to treat hepatitis C infections. Your healthcare professional will monitor your hepatitis B levels and may do blood tests before, during and after hepatitis C treatment. Your healthcare professional may prescribe hepatitis B treatment.

  • have HIV-1
  • have kidney disease
  • have any other medical condition
  • are pregnant of plan to become pregnant

It is not known if Sunvepra™ passes into your breast milk. You and your healthcare professional should decide if you will take Sunvepra™ or breastfeed. You should not do both.

  • are taking any medications

If you are taking Sunvepra™ with Daklinza®, peginterferon alfa and ribavirin: You or your sexual partner should not become pregnant during treatment and for 6 months after treatment ends.

  • Females and males must use 2 effective forms of birth control during treatment and for the 6 months after treatment with peginterferon alfa and ribavirin. Talk with your healthcare professional about forms of birth control that may be used during this time. Some oral birth control pills may not work with Sunvepra™.
  • Females must have a negative pregnancy test before starting treatment with peginterferon alfa and ribavirin, every month while being treated, and every month for 6 months after your treatment ends.
  • If you or your female partner becomes pregnant while taking Sunvepra™ tell your healthcare professional right away.

If you are NOT taking peginterferon alfa and ribavirin, the following information about pregnancy applies:

  • The effects of Sunvepra™ on pregnancy and the unborn child are not known. If you can become pregnant, talk with your healthcare professional what forms of birth control to use. Some oral birth control pills may not work with Sunvepra™.

Some people taking Sunvepra™ have abnormal results on tests that show how well the liver is working. Your healthcare professional may request that you have blood tests every 2 weeks for the first 12 weeks and then every 4 weeks while you take Sunvepra™. If the test results are not at normal levels, your healthcare professional may instruct you to stop taking Sunvepra™.

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To help avoid side effects and make sure you are using your medicines correctly, talk to your healthcare professional before you take Technivie™. Talk about any health conditions or problems you may have, including if you:

(read more)

Ethinyl estradiol is usually found in birth control pills. However, not all birth control pills have ethinyl estradiol. You must not use medicines that have ethinyl estradiol while taking Technivie™. Your healthcare professional will ask you to stop or change to a different type of birth control while you are taking Technivie™.

  • have any other medical condition

You should not take Technivie™ if you are taking everolimus. The dose of everolimus cannot be adjusted to maintain the correct drug levels when given with Technivie™.

If you are taking tacrolimus, you should talk to your healthcare professional about the risks and benefits of taking Technivie™ at the same time and consider:

  • Serious and life-threatening side effects have occurred when taking Technivie™ with tacrolimus
  • Your healthcare professional may order blood tests to check tacrolimus levels in your blood at the beginning and during treatment with Technivie™

Talk with your healthcare professional if you are taking cyclosporine for your transplant. The levels of this medicine can change when taken with Technivie™. Your healthcare professional will choose how much cyclosporine you need to take:

  • with Technivie™
  • when you have completed Technivie™
  • if you have to stop taking Technivie™ for any reason
  • have liver problems other than HCV infection
  • also have HIV infection

It is not known if Technivie™ passes into your breast milk. You and your healthcare professional should decide if you will take Technivie™ or breastfeed. You should not do both.

Taking antiviral drugs such as Technivie™ may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment
  • to see the hepatitis B levels in your blood
  • and may order hepatitis B treatment
  • Females must have a negative pregnancy test before starting Technivie™ and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Technivie™ with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Technivie™ and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control that you can use.
  • If you or your partner becomes pregnant while taking Technivie™ and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.

Other warnings you should know about:

These severe liver problems can lead to the need for a liver transplant, or can lead to death.

Rises in liver tests have occurred when Technivie™ was taken in studies. Contact your healthcare professional right away if you have symptoms like those listed below since these may mean you have a serious problem with your liver:

  • loss of appetite (do not feel like eating)
  • stomach ache
  • swelling of your stomach area
  • nausea (feeling sick in the stomach)
  • vomiting
  • feeling tired or weak
  • yellowing of the skin and eyes
  • confusion
  • dark urine and pale stool

It is not known if taking Technivie™ is safe or will work in children under 18 years of age.

Your healthcare professional may do blood tests before you start taking, and while you are on your medicines. This is to help check if the medicines are working for you.

(read less)

To help avoid side effects and ensure you take your medicine properly, talk to your healthcare professional before you take Vosevi. Talk about any health problems you may have, including if you:

(read more)
  • have liver problems other than hepatitis C infection.
  • have HIV.
  • have severe kidney disease or you are on dialysis.
  • are taking heart medication such as amiodarone (e.g. Cordarone®). Your healthcare professional may monitor your heart function while taking Vosevi.
  • were born with the rare problem of not being able to tolerate galactose (severe lack of lactase or cannot absorb glucose or galactose). Vosevi has lactose.

Taking antiviral drugs such as Vosevi™ may increase hepatitis B activity. This can lead to liver problems such as liver failure and death. Contact your healthcare professional if:

  • you have never been tested for hepatitis B.
  • you know you have a current hepatitis B infection.
  • you have had a previous hepatitis B infection.

Your healthcare professional may do blood tests:

  • before hepatitis C treatment.
  • to see the hepatitis B levels in your blood.
    • and may order hepatitis B treatment.

If you are pregnant or plan to become pregnant, talk to your healthcare professional before you take this medicine. The effects of Vosevi during pregnancy are not known. Avoid pregnancy while taking Vosevi. Tell your healthcare professional if you become pregnant while taking Vosevi.

If you are breastfeeding or plan to breastfeed, talk to your healthcare professional about the best way to feed your baby. Do not breastfeed while taking Vosevi.

Another warning you should know about:
Because Vosevi already contains sofosbuvir, do not take Vosevi with any other medicines that have sofosbuvir (e.g., Sovaldi®, Harvoni®, Epclusa®).

(read less)

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Zepatier®. Talk about any health conditions or problems you may have, including if you:

(read more)
  • have ever taken any medicine for hepatitis C
  • have liver problems other than hepatitis C infection
  • have had, or are waiting for, a liver transplant
  • have any other medical conditions
  • are pregnant, or plan to become pregnant, breastfeed or plan to breastfeed

Tell your healthcare professional right away if you develop the following symptoms of liver problems such as:

  • loss of appetite
  • nausea and vomiting
  • feeling tired and weak
  • abdominal pain
  • yellowing of your skin or eyes
  • colour changes in your stool

Taking antiviral drugs such as Zepatier® may increase hepatitis B activity. This can lead to liver problems such as liver failure and death.

Contact your healthcare professional if:

  • you have never been tested for hepatitis B
  • you know you have a current hepatitis B infection
  • you have had a previous hepatitis B infection

Your healthcare professional may do blood tests:

  • before hepatitis C treatment
  • to see the hepatitis B levels in your blood
  • and may order hepatitis B treatment

Your healthcare professional will decide if Zepatier® is right for you.

Other warnings you should know about:

  • Tell your healthcare professional if you are pregnant or plan to become pregnant.
  • We don’t know if Zepatier® will harm your baby while you are pregnant.

Zepatier® may be used with ribavirin. Ribavirin may cause birth defects and death of the unborn baby. Extreme care must be taken to avoid becoming pregnant.

  • Females must have a negative pregnancy test before starting Zepatier® and ribavirin, every month while on the medicine, and for 6 months after stopping them.
  • You or your partner should not become pregnant while taking Zepatier® with ribavirin and for 6 months after you have stopped taking them.
  • You and your partner must use 2 kinds of birth control while taking Zepatier® and ribavirin and for 6 months after you have stopped taking them.
  • Talk to your healthcare professional about the kind of birth control that you can use.
  • If you or your partner becomes pregnant while taking Zepatier® and ribavirin or within 6 months after you stop taking them, tell your healthcare professional right away.
  • Tell your healthcare professional if you are breastfeeding or planning to breastfeed.
  • We don’t know if Zepatier® gets in your breast milk and gets passed to your baby.
  • It is recommended that you do not breastfeed while taking Zepatier®.
  • Read the ribavirin package leaflet for important breastfeeding information.
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What side effects are possible with this treatment?

When taken with sofosbuvir and ribavirin
Common or very common:

(read more)
  • headache
  • fatigue
  • nausea
  • rash
  • diarrhea
  • difficulty in sleeping

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

Most common:

  • feeling tired
  • headache
(read more)

When sofosbuvir (one of the medicines in Epclusa®) is used with other hepatitis C medicines (e.g., daclatasvir [Daklinza®], simeprevir [Galexos®] or ledipasvir) and amiodarone (a heart drug), side effects may be:

  • slow heartbeat leading to a need for a pacemaker or death

Contact your healthcare professional immediately if you have symptoms of a slow heartbeat such as:

  • fainting or near-fainting
  • dizziness or lightheadedness
  • not feeling well
  • feeling weak or very tired
  • shortness of breath
  • chest pains
  • confusion or memory problems

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

When taken with ribavirin and peginterferon alfa

Very common (may affect more than 1 in 10 people):

  • itching of the skin
  • skin rash
(read more)

Common (affect fewer than 1 in 10 people):

  • increased bilirubin levels in your blood
  • being sensitive to sunlight (photosensitivity)
  • constipation

When taken with sofosbuvir

Common (affect fewer than 1 in 10 people):

  • itching of the skin
  • skin rash*
  • constipation
  • being sensitive to sunlight (photosensitivity)
  • increased ‘bilirubin’ levels in your blood

* Note: Skin rash may affect more than 1 in 10 people (very common) when Galexos® is used in combination with sofosbuvir for 24 weeks.

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

Most common:

  • feeling tired
  • headache

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

Common (affect fewer than 1 in 10 people):

  • feeling tired or weak
  • headache
(read more)

When taken with ribavirin
Common (affect fewer than 1 in 10 people):

  • feeling tired or weak
  • headache
  • itching
  • nausea (feeling sick in the stomach)
  • trouble sleeping

Hypersensitivity (allergic reactions) with symptoms such as swollen lips and tongue have been reported for Holkira Pak®.

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

The most common side effects of MAVIRET are:

  • tiredness
  • headache
  • nausea (feeling sick in the stomach)

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

When taken with ribavirin:
Common:

  • feeling tired
  • headache
  • trouble sleeping
  • feeling sad or annoyed
  • nausea
  • low red blood cells (in a blood test)
(read more)

When taken with ribavirin and peginterferon alfa
Common:

  • feeling tired
  • headache
  • trouble sleeping
  • feeling sad or annoyed
  • rash
  • nausea
  • low red blood cells or white blood cells (in a blood test)

When Sovaldi® is used with other hepatitis C medicines (e.g., daclatasvir [Daklinza®], simeprevir [Galexos®], or ledipasvir) and amiodarone (a heart drug), side effects may be:

  • slow heart beat leading to a need for a pacemaker or death

Contact your healthcare professional immediately if you have symptoms of a slow heartbeat such as:

  • fainting or near-fainting
  • dizziness or lightheadedness
  • not feeling well
  • feeling weak or very tired
  • shortness of breath
  • chest pains
  • confusion or memory problems

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

Liver problems:
Some people taking Sunvepra™ have abnormal results on tests that show how well the liver is working.

(read more)

Most common side effects when taken with Daklinza®:

  • headache
  • tiredness

Most common side effects when taken with Daklinza®, peginterferon alfa, and ribavirin:

  • tiredness
  • headache
  • itching
  • unusual weakness
  • flu-like symptoms
  • difficulty sleeping (insomnia)
  • low red blood cell count
  • rash
  • hair loss
  • irritability
  • nausea

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

When taken with ribavirin:
Common:

  • headache
  • itching
  • feeling tired or weak
  • trouble sleeping
  • too much of a normal substance called bilirubin in the blood that could cause yellowing of the skin and eye

Other side effects:
You could also have an allergic reaction. Symptoms of allergic reactions could be swelling of the mouth, throat, hands and feet, trouble breathing, rash, and itching.

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

Most common:

  • headache
  • feeling tired
  • diarrhea
  • feeling sick in the stomach
  • problem with getting to sleep
  • less energy or strength
(read more)

When sofosbuvir (one of the medicines in Vosevi) is used with other hepatitis C medicines (e.g., daclatasvir [Daklinza®], simeprevir [Galexos®] or ledipasvir) and amiodarone (a heart drug), side effects may be:

  • slow heartbeat leading to a need for a pacemaker or death

Contact your healthcare professional immediately if you have symptoms of a slow heartbeat such as:

  • fainting or near-fainting.
  • dizziness or lightheadedness.
  • not feeling well.
  • feeling weak or very tired.
  • shortness of breath.
  • chest pains.

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)

Very common (more than 10%):

  • headache
  • feeling tired
(read more)

Common (1-10%):

  • abdominal pain
  • constipation
  • diarrhea
  • dry mouth
  • vomiting
  • nausea
  • weakness
  • decreased appetite
  • joint pain
  • muscle pain
  • dizziness
  • anxiety
  • depression
  • difficulty sleeping
  • irritability
  • hair loss
  • itching

When taken with ribavirin
Common and very common:

  • headache
  • feeling tired or weak
  • nausea or vomiting
  • itching
  • muscle aches
  • rash
  • trouble sleeping
  • low red blood cell counts
  • shortness of breath
  • indigestion
  • feeling less hungry
  • cough
  • feeling irritable

When taken with sofosbuvir
Common:

  • headache
  • nausea
  • diarrhea
  • feeling tired

These are not all the possible side effects you may feel when you take this medicine. If you have a side effect that is not listed here or becomes bad enough to get in the way of your daily tasks, talk to your healthcare professional (doctor, nurse, or pharmacist) for more information.

(read less)
What serious side effects may occur with this treatment?

Daklinza® used with sofosbuvir and a medicine called amiodarone may cause serious side effects, including:

(read more)
  • slow heart rate (bradycardia). Get medical help right away if you take amiodarone with sofosbuvir and Daklinza®, and get any of the following symptoms:
    • fainting or near fainting
    • weakness
    • chest pain
    • dizziness or lightheadedness
    • tiredness
    • confusion
    • not feeling well
    • shortness of breath
    • memory problems

Commonly associated with ribavirin therapy:
Very common:

  • low red blood cell count (anemia). Symptoms include:
    • tiredness
    • headache
    • shortness of breath
    • dizziness
    • looking pale

This is not a complete list of possible side effects. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information. If you experience any of these serious side effects, or have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

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Does not apply

Common (affect fewer than 1 in 10 people):

(read more)
  • sensitivity to sunlight
    • Symptoms:
      • sunburn
      • blistering
      • redness of the skin
      • swelling of the skin

This is not a complete list of possible side effects. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information. If you experience any of these serious side effects, or have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

(read less)

Serious allergic reactions

Symptoms:

  • skin rashes with or without blisters
  • swelling of the face, lips, tongue or throat
  • trouble breathing
(read more)

When used in combination with a medicine called amiodarone (Cordarone®, a heart drug):
Rare

  • slow heartbeat (bradycardia) leading to a need for a pacemaker or death, with symptoms such as:
    • near-fainting or fainting
    • dizziness or lightheadedness
    • not feeling well
    • feeling weak or very tired
    • shortness of breath
    • chest pains
    • confusion or memory problems

Contact your healthcare professional immediately if you have symptoms of a slow heartbeat such as the ones listed above.

This is not a complete list of possible side effects. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information. If you experience any of these serious side effects, or have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

(read less)

Does not apply

Does not apply

When taken with ribavirin and peginterferon alfa:
Very common:

(read more)
  • low red blood cells (anemia) with symptoms such as:
    • feeling tired
    • headache
    • shortness of breath
    • dizziness
    • looking pale
  • low white blood cells (neutropenia) with symptoms such as:
    • increased infections
  • low blood platelets (thrombocytopenia) with symptoms such as:
    • bruising and increased chance of bleeding

This is not a complete list of possible side effects. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information. If you experience any of these serious side effects, or have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

(read less)

When used with peginterferon alfa and ribavirin:
Very common:

(read more)
  • low red blood cell counts (anemia)
    • Symptoms:
      • tiredness
      • headache
      • shortness of breath
      • dizziness
      • looking pale
  • low white blood cell counts (neutropenia)
    • Symptoms:
      • increased infections

Common:

  • low blood platelet (thrombocytopenia)
    • Symptoms:
      • bruising and increased tendency to bleed

These side effects are commonly associated with peginterferon alfa and ribavirin therapy.

This is not a complete list of possible side effects. Talk to your healthcare professional (doctor, nurse, or pharmacist) for more information. If you experience any of these serious side effects, or have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

(read less)

Does not apply

Does not apply

Does not apply

Epclusa, Harvoni, Sovaldi and Vosevi are trademarks of Gilead Sciences Inc. or its related companies.
All trademarks and registered trademarks are property of their respective owners.
The contents of this table are accurate at the time of publication (November 2017) and are subject to the website Terms of Use.

You can help improve the safe use of health products for Canadians by reporting serious and unexpected side effects to Health Canada. Your report may help to identify new side effects and change the product safety information.

Three ways to report:

  • Online at MedEffect;
  • By calling 1-866-234-2345 (toll-free);
  • By completing a Consumer Side Effect Reporting Form and sending it by:
    • Fax to 1-866-678-6789 (toll-free), or
    • Mail to:
      Canada Vigilance Program
      Health Canada, Postal Locator 1908C
      Ottawa, ON
      K1A 0K9

Postage paid labels and the Consumer Side Effect Reporting Form are available at MedEffect.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.